Matrix Stiffness Regulates TGFβ1‐Induced αSMA Expression via a G9a‐LATS‐YAP Signaling Cascade

Matrix Stiffness Regulates TGFβ1‐Induced αSMA Expression via a G9a‐LATS‐YAP Signaling Cascade

ABSTRACT Extracellular matrix stiffness is enhanced in cancer and fibrosis; however, there is limited knowledge on how matrix mechanics modulate expression and signaling of the methyltransferase G9a. Here, we show that matrix stiffness and transforming growth factor (TGF)‐β1 signaling together regul...

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Bibliographic Details
Main Authors: Chinmay S. Sankhe, Jessica L. Sacco, Victoria L. Crunkleton, Malcom Díaz García, Matthew J. Bierowski, David Vidotto Rezende Soares, Jacob A. Karnick, Rachel L. Cecco, Arefeh Abbasi, Joy Kirigo, Thomas K. Wood, Esther W. Gomez
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:FASEB BioAdvances
Subjects:
epigenomics
epithelial cells
extracellular matrix
histone methyltransferases
hydrogels
mammary gland
Online Access:https://doi.org/10.1096/fba.2025-00117
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https://doi.org/10.1096/fba.2025-00117

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