Environmental enrichment attenuates social isolation-exacerbated postoperative cognitive dysfunction in aged mice via inhibition of RAGE-HMGB1 proinflammatory signaling

Environmental enrichment attenuates social isolation-exacerbated postoperative cognitive dysfunction in aged mice via inhibition of RAGE-HMGB1 proinflammatory signaling

Microglial overactivation, leading to neuroinflammation, plays a pivotal role in the development of postoperative cognitive dysfunction (POCD). However, the reasons behind varying inflammatory and cognitive reactions to similar surgical stresses among individuals remain enigmatic. Social isolation (...

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Bibliographic Details
Main Authors: Sha Li, Hongyan Wang, Mingzhe Qin, Wei Huang, Huifang Gao, Xiaoyang Song, Xiaolong Chen, Bixi Li
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Brain Research Bulletin
Subjects:
Postoperative cognitive dysfunction
Social isolation
Neuroinflammation
RAGE-HMGB1 axis
Environmental enrichment
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025002746
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