Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier

Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier

Objective: Migrasomes, an emerging class of migration-facilitating membranous extracellular vesicles, remain largely uncharted in the intricate landscape of tumor metastasis. This study aimed to illuminate the roles and mechanisms underlying cancer cell-derived migrasomes in breast cancer brain meta...

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Bibliographic Details
Main Authors: Song Wang, Guohao Gu, Xinmiao Xian, Jun Li, Di Zhang, Jianran Guo, Anqi Zhang, Shen Chen, Dong Yan, Bingwu Yang, Meng An, Wei Zhang, Bo Fu
Format: Article
Language:English
Published: China Anti-Cancer Association 2025-06-01
Series:Cancer Biology & Medicine
Subjects:
breast cancer brain metastasis
migrasome
blood-brain barrier
atf6
endoplasmic reticulum stress
Online Access:https://www.cancerbiomed.org/content/22/6/690
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