Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression

ABSTRACT Activin‐A is elevated in pulmonary arterial hypertension (PAH) patients, and reportedly suppresses BMPR‐II. This suggests one mechanism of action for PAH drug, sotatercept, an activin‐ligand trap. However, we were unable to confirm that activin‐A reduces BMPR‐II in pulmonary endothelial cel...

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Autori principali: Benjamin J. Dunmore, Nobuhiro Kikuchi, Wei Li, Paul D. Upton, Nicholas W. Morrell
Natura: Articolo
Lingua:inglese
Pubblicazione: Wiley 2025-04-01
Serie:Pulmonary Circulation
Accesso online:https://doi.org/10.1002/pul2.70095
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