Dosimetric Comparison of VMAT Alone and VMAT with HDR Brachytherapy Boost Using Clinical and Biological Dose Models in Localized Prostate Cancer

Dosimetric Comparison of VMAT Alone and VMAT with HDR Brachytherapy Boost Using Clinical and Biological Dose Models in Localized Prostate Cancer

Background: Combining external beam radiotherapy (EBRT) with high-dose-rate (HDR) brachytherapy (BT) enables biologically effective dose escalation in prostate cancer. However, comparative evaluation of such regimens using radiobiological modeling remains limited. Methods: Dose regimens based on cli...

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Bibliographic Details
Main Authors: Manuel Guhlich, Olga Knaus, Arne Strauss, Laura Anna Fischer, Jann Fischer, Stephanie Bendrich, Sandra Donath, Leif Hendrik Dröge, Martin Leu, Stefan Rieken, Annemarie Uhlig, Markus Anton Schirmer, Andrea Hille
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Current Oncology
Subjects:
prostate cancer
radiotherapy
high-dose-rate brachytherapy (HDR-BT)
external beam radiotherapy (EBRT)
biologically effective dose (BED)
organs at risk (OARs)
Online Access:https://www.mdpi.com/1718-7729/32/6/360
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