Adaptation of an in vitro one-compartment pharmacodynamic chemostat for testing efficacy of ceftazidime against Burkholderia pseudomallei outside a BSL3 facility

Adaptation of an in vitro one-compartment pharmacodynamic chemostat for testing efficacy of ceftazidime against Burkholderia pseudomallei outside a BSL3 facility

Non-clinical pharmacokinetic-pharmacodynamic (PKPD) models are crucial in the initial design of drug-dosage regimens and in drug development but has rarely been employed for testing high-risk organisms due to stringent handling procedures. Burkholderia pseudomallei is classified as a Tier 1 select a...

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Main Authors: Hana Farizah Zamri, Mohammad Ridhuan Mohd Ali, Ahmad Izzan Irfan Sha'ari, Nurul Husna Mohd Mazalan, Norazah Ahmad, Nur Asyura Nor Amdan, Nusaibah Abdul Rahim, Zakuan Zainy Deris
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:MethodsX
Subjects:
In vitro one-compartment chemostat for evaluating ceftazidime PK/PD against B. pseudomallei
Online Access:http://www.sciencedirect.com/science/article/pii/S2215016125000159
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