Analysis of differential gene expression of PBMC for the in vitro detection of drug sensitization

Analysis of differential gene expression of PBMC for the in vitro detection of drug sensitization

Background: The detection of drug-specific activation of T cells in the lymphocyte transformation test (LTT) is mainly based on cell proliferation or cytokine secretion. However, the LTT presents with a varying sensitivity and specificity. The aim of our study was to analyse the genome wide gene exp...

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Main Authors: Andreas Glässner, Michael Steffens, Amol Fatangare, Gerda Wurpts, Per Hoffmann, Philipp N. Deck, Christine Krämer, Stefani Röseler, Albert Sickmann, Markus M. Nöthen, Amir S. Yazdi, Bernhardt Sachs
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Allergology International
Subjects:
Drug allergy
ELISA
Lymphocyte transformation test
Peripheral blood mononuclear cells
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893024001515
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http://www.sciencedirect.com/science/article/pii/S1323893024001515

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