Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases
Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe syste...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2024-10-01
|
| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0044 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839638064471736320 |
|---|---|
| author | Chi Lui Chan Yilu Sun Xiaowen Mao Hansen Chen Jia Zhao Jianhui Rong |
| author_facet | Chi Lui Chan Yilu Sun Xiaowen Mao Hansen Chen Jia Zhao Jianhui Rong |
| author_sort | Chi Lui Chan |
| collection | DOAJ |
| description | Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemic toxicity. The aim of this review was to discuss the druggability, molecular targets, and nanocarrier delivery of the natural triterpenoid, celastrol, against chronic diseases. We sequentially investigated the physicochemical properties of celastrol using online tools (pkCSM and SwissADME), reviewed the recent studies on the molecular mechanisms underlying the therapeutic effects of celastrol, and examined the potential of nanoparticle-mediated delivery systems for safe and effective delivery of celastrol. The cancer-related targets and pathways involved were further predicted through network pharmacologic analysis. This review provides molecular insights into the pharmacologic activities and molecular mechanisms underlying celastrol, as well as useful information for the selection of nanocarrier drug delivery system for the clinical delivery of celastrol against various chronic diseases. |
| format | Article |
| id | doaj-art-c74be31d0efa42988e7b9a5ccc6b9ec3 |
| institution | Matheson Library |
| issn | 2737-7946 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj-art-c74be31d0efa42988e7b9a5ccc6b9ec32025-07-05T16:00:06ZengCompuscript LtdActa Materia Medica2737-79462024-10-013438340410.15212/AMM-2024-0044Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseasesChi Lui ChanYilu SunXiaowen MaoHansen ChenJia ZhaoJianhui RongCelastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hindered by its low bioavailability and severe systemic toxicity. The aim of this review was to discuss the druggability, molecular targets, and nanocarrier delivery of the natural triterpenoid, celastrol, against chronic diseases. We sequentially investigated the physicochemical properties of celastrol using online tools (pkCSM and SwissADME), reviewed the recent studies on the molecular mechanisms underlying the therapeutic effects of celastrol, and examined the potential of nanoparticle-mediated delivery systems for safe and effective delivery of celastrol. The cancer-related targets and pathways involved were further predicted through network pharmacologic analysis. This review provides molecular insights into the pharmacologic activities and molecular mechanisms underlying celastrol, as well as useful information for the selection of nanocarrier drug delivery system for the clinical delivery of celastrol against various chronic diseases.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0044 |
| spellingShingle | Chi Lui Chan Yilu Sun Xiaowen Mao Hansen Chen Jia Zhao Jianhui Rong Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases Acta Materia Medica |
| title | Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases |
| title_full | Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases |
| title_fullStr | Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases |
| title_full_unstemmed | Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases |
| title_short | Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases |
| title_sort | druggability molecular targets and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0044 |
| work_keys_str_mv | AT chiluichan druggabilitymoleculartargetsandnanocarrierdeliveryofnaturaltriterpenoidcelastrolagainstchronicdiseases AT yilusun druggabilitymoleculartargetsandnanocarrierdeliveryofnaturaltriterpenoidcelastrolagainstchronicdiseases AT xiaowenmao druggabilitymoleculartargetsandnanocarrierdeliveryofnaturaltriterpenoidcelastrolagainstchronicdiseases AT hansenchen druggabilitymoleculartargetsandnanocarrierdeliveryofnaturaltriterpenoidcelastrolagainstchronicdiseases AT jiazhao druggabilitymoleculartargetsandnanocarrierdeliveryofnaturaltriterpenoidcelastrolagainstchronicdiseases AT jianhuirong druggabilitymoleculartargetsandnanocarrierdeliveryofnaturaltriterpenoidcelastrolagainstchronicdiseases |