Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment

The lipid composition of the epidermis plays a critical role in the skin’s barrier function, and defects in lipid synthesis or assembly can cause a spectrum of skin diseases, ranging from dry skin to severe ichthyoses. The aim of this study was to develop an in vitro model of human skin with tunable...

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Bibliographic Details
Main Authors: Durotimi O. Dina, Miriam Maiellaro, Emanuela Camera, John T. Connelly
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:JID Innovations
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667026725000396
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