Comprehensive analysis of pyroptosis-related genes in psoriasis and targeted gene editing of CASP1 and CASP5 using lipid nanoparticles to alleviate skin inflammation

Psoriasis is a chronic inflammatory skin disorder driven by immune dysregulation and excessive cell death. Pyroptosis, a form of inflammatory programmed cell death, has not been extensively studied in the context of psoriasis despite its importance in inflammation. In this study, we systematically a...

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Bibliographic Details
Main Authors: Gexiao Xu, Guanyi Ma, Jiachen Sun, Xiaoyan Yu, Jie Sun, Bing Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
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Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1639869/full
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