Immunoglobulin A carries sulfated and O-acetylated N-glycans primarily at the tailpiece site – strategies for site-specific N-glycan identification

Sulfated N-glycans from human immunoglobulin A (IgA) were recently discovered via glycomic approaches. However, their site-specific description is still pending. Certain N-glycan structures at specific N-glycosylation sites in IgA are crucial for microbial neutralization and effector functions. For...

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Bibliographic Details
Main Authors: Frania J. Zuniga-Banuelos, Greta Lemke, Marcus Hoffmann, Udo Reichl, Erdmann Rapp
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Molecular Biosciences
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Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1595173/full
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