Metformin prevents oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome via activation of Nrf2-HO-1 pathway

Metformin prevents oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome via activation of Nrf2-HO-1 pathway

Objective The purpose of the study is to investigate therapeutic effects of metformin on improving PCOS and the underlying mechanism.Methods PCOS modeling and metformin treatment in rats was performed by subcutaneous injection of dehydroepiandrosterone (DHEA) daily, high-fat diet feeding, and intrag...

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Bibliographic Details
Main Authors: Jin-Jing Li, Hong-Lian Wu, Yang Lv, Ye-Min Qin, Xi-Xi Qiu, Xi-Xi Cai
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gynecological Endocrinology
Subjects:
Polycystic ovary syndrome
metformin
granulosa cells
oxidative stress
apoptosis
Online Access:https://www.tandfonline.com/doi/10.1080/09513590.2025.2528815
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https://www.tandfonline.com/doi/10.1080/09513590.2025.2528815

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