Green Tea Extract Containing Epigallocatechin-3-Gallate Facilitates Bone Formation and Mineralization by Alleviating Iron-Overload-Induced Oxidative Stress in Human Osteoblast-like (MG-63) Cells

Green Tea Extract Containing Epigallocatechin-3-Gallate Facilitates Bone Formation and Mineralization by Alleviating Iron-Overload-Induced Oxidative Stress in Human Osteoblast-like (MG-63) Cells

Secondary iron overload exacerbates osteoporosis by elevating reactive oxygen species (ROS), which suppress osteoblast function and enhance osteoclast activity, disrupting bone remodeling. Reducing iron overload and oxidative stress may improve bone health. Epigallocatechin-3-gallate (EGCG), the mai...

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Bibliographic Details
Main Authors: Honghong Xu, Orawan Khantamat, Woranontee Korsieporn, Narisara Paradee, Jin Li, Yanping Zhong, Somdet Srichairatanakool, Pimpisid Koonyosying
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antioxidants
Subjects:
green tea
EGCG
iron overload
oxidative stress
bone formation
bone mineralization
Online Access:https://www.mdpi.com/2076-3921/14/7/874
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