Epoxy-Functionalized Isatin Derivative: Synthesis, Computational Evaluation, and Antibacterial Analysis

Epoxy-Functionalized Isatin Derivative: Synthesis, Computational Evaluation, and Antibacterial Analysis

Background/Objectives: The current need for new antibacterial compounds that target non-classical pathways is highlighted by the emergence of multidrug-resistant <i>Klebsiella pneumoniae</i>. In the development of antibiotics, DNA adenine methyltransferase (Dam), a key regulator of bacte...

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Bibliographic Details
Main Authors: Deepanjali Shukla, Iqbal Azad, Mohd Arsh Khan, Ziaul Husain, Azhar Kamal, Sabahat Yasmeen Sheikh, Ibrahim Alotibi, Varish Ahmad, Firoj Hassan
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antibiotics
Subjects:
ADMET
antibacterial
dam protein
epoxy-functionalized isatin
<i>K. pneumoniae</i>
molecular docking
Online Access:https://www.mdpi.com/2079-6382/14/6/595
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