Vertical Hot-Melt Extrusion: The Next Challenge in Innovation

Vertical Hot-Melt Extrusion: The Next Challenge in Innovation

<b>Background/Objectives:</b> Hot-melt extrusion (HME) has become a key technology in pharmaceutical formulation, particularly for enhancing the solubility of poorly soluble Active Pharmaceutical Ingredients (APIs). While horizontal HME is widely adopted, vertical HME remains underexplor...

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Bibliographic Details
Main Authors: Maël Gallas, Ghouti Medjahdi, Pascal Boulet, Victoire de Margerie
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceutics
Subjects:
vertical hot-melt extrusion
drug delivery systems
extrusion processing parameters
amorphous solid dispersions
solubility
bioavailability
Online Access:https://www.mdpi.com/1999-4923/17/7/939
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