Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model.

Phenotypic plasticity contributes significantly to treatment failure in many cancers. Despite the increased prevalence of experimental studies that interrogate this phenomenon, there remains a lack of applicable quantitative tools to characterise data, and importantly to distinguish between resistan...

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Bibliographic Details
Main Authors: Alexander P Browning, Rebecca M Crossley, Chiara Villa, Philip K Maini, Adrianne L Jenner, Tyler Cassidy, Sara Hamis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1013202
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