Molecular Dynamics Simulation Study of Stabilizer Association with the Val122Ile Transthyretin Variant
The tetrameric protein transthyretin (TTR) transports the hormone thyroxine in plasma and cerebrospinal fluid. Certain point mutations of TTR, including the Val122Ile mutation investigated here, destabilize the tetramer leading to its dissociation, misfolding, aggregation, and the eventual buildup o...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Biophysica |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4125/5/2/16 |
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