Ser/Thr phosphorylation of Mycobacterium tuberculosis type II RelK toxin by PknK destabilizes TA interaction and interferes with toxin neutralization

Ser/Thr phosphorylation of Mycobacterium tuberculosis type II RelK toxin by PknK destabilizes TA interaction and interferes with toxin neutralization

ABSTRACT Toxin-antitoxin (TA) modules represent genetic elements implicated in bacterial persistence. Mycobacterium tuberculosis encodes 90+ TA modules, the majority of which are type II, comprising of a toxin component and an antitoxin counterpart that neutralizes the toxin. Under stressful environ...

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Main Authors: Shafinaz Rahman Sarah, Abhishek Garg, Sadiyah Afroz, Shaleen Korch, Arjun Ray, Amita Gupta, Vandana Malhotra
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Mycobacterium tuberculosis
toxin-antitoxin modules
persistence
post-translational modification
Ser/Thr phosphorylation
PknK
Online Access:https://journals.asm.org/doi/10.1128/mbio.01068-25
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https://journals.asm.org/doi/10.1128/mbio.01068-25

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