Evaluation of lithium chloride safety and toxicokinetics for injection in minipigs

Evaluation of lithium chloride safety and toxicokinetics for injection in minipigs

Lithium salts are known to treat bipolar disorder. Their high potential as neuroprotective agents in cerebral ischemia determines relevance for preclinical studies for the registration of new drugs based on them. Aim of the study was to investigate the toxic properties and local tolerability with an...

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Bibliographic Details
Main Authors: V. M. Kosman, A. Yu. Romanenko, M. V. Karlina, N. M. Faustova, E. V. Mazukina, A. N. Kuzovlev, A. V. Grechko, R. A. Cherpakov, M. N. Makarova, V. G. Makarov
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Siberian Branch Publishing House 2025-01-01
Series:Сибирский научный медицинский журнал
Subjects:
lithium chloride
repeated intravenous injection
toxicity
local tolerability
bioanalytical assay
serum
colorimetric method with quinizarin
Online Access:https://sibmed.elpub.ru/jour/article/view/1839
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