Myricetin protects against doxorubicin-induced acute kidney injury in rats by mitigating oxidative damage and apoptotic response

Myricetin protects against doxorubicin-induced acute kidney injury in rats by mitigating oxidative damage and apoptotic response

IntroductionDoxorubicin (DOX) is a potent anti-neoplastic agent widely preferred in treating various tumors. However, DOX’s off-target toxicity in healthy tissues, such as nephrotoxicity, limits its clinical utilization. DOX generates oxidative stress and apoptosis in the kidneys, which stimulates c...

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Bibliographic Details
Main Authors: Muhammed Talha Karadogan, Betul Cicek, Kagan Tolga Cinisli, Ali Sefa Mendil, Mustafa Ozkaraca, Furkan Yilmaz, Halis Suleyman
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
Acut kidney injury
antioxidant
apoptosis
doxorubicin
myricetin
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1601628/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1601628/full

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