Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability

Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability

Abstract Mycobacterium tuberculosis (M.tb) infection infects human alveolar macrophages (HAMs). In freshly isolated HAMs from 28 healthy adults, we observe large inter-individual differences in bacterial uptake and growth, with tenfold variation in M.tb load by 72 h. While M.tb infection triggers ex...

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Main Authors: Wolfgang Sadee, Ian H. Cheeseman, Audrey Papp, Maciej Pietrzak, Michal Seweryn, Xiaofei Zhou, Shili Lin, Amanda M. Williams, Mark D. Wewers, Heather M. Curry, Hao Zhang, Hong Cai, Carine Kunsevi-Kilola, Happy Tshivhula, Gerhard Walzl, Blanca I. Restrepo, Léanie Kleynhans, Katharina Ronacher, Yufeng Wang, Eusondia Arnett, Abul K. Azad, Larry S. Schlesinger
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08337-9
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https://doi.org/10.1038/s42003-025-08337-9

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