Differential substrate degradation by super-degron: EGFP in wild-type mouse cells, PD-1 requires CRBN humanization

Differential substrate degradation by super-degron: EGFP in wild-type mouse cells, PD-1 requires CRBN humanization

Summary: Protein knockdown using a zinc finger degron tag and thalidomide analogs was previously considered ineffective in mouse cells. However, using EGFP as an indicator, we found that a super-degron tag (SD) enables degradation in mouse cells when combined with iberdomide or mezigdomide. While SD...

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Main Authors: Chie Naruse, Ojiro Ishibashi, Masatoshi Ohgushi, Hirohiko Imai, Tomoko Matsuzaki, Xuchi Pan, Tatsuhiko Miyazaki, Yuka Shidahara, Yu Shirakawa, Fumihiro Sugiyama, Masahide Asano
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012532
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http://www.sciencedirect.com/science/article/pii/S2589004225012532

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