Direct Expression of CPT1a Enables a High Throughput Platform for the Discovery of CPT1a Modulators

Direct Expression of CPT1a Enables a High Throughput Platform for the Discovery of CPT1a Modulators

Carnitine palmitoyltransferase 1 (CPT1), which catalyzes the rate-limiting step of fatty acid oxidation, has been implicated in therapeutic approaches to several human diseases characterized by aberrant lipid metabolism. The isoform-specific quantification of CPT1 activity is essential in the charac...

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Main Authors: Jason Chen, Tuyen Tran, Anthony Wong, Luofei Wang, Pranavi Annaluru, Vibha Sreekanth, Samika Murthy, Laasya Munjeti, Tanya Park, Utkarsh Bhat, Glynnis Leong, Yumeng Li, Simeng Chen, Natalie Kong, Rushika Raval, Yining Xie, Shreya Somani, Aditi Manohar Bhambhani, Zoey Zhu, Landen Chu, Kimai Dosch, Edward Njoo, Zhan Chen
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Applied Biosciences
Subjects:
carnitine palmitoyltransferase activity assay
CPT1 inhibitor
CPT1 modulators
fatty acid oxidation
Online Access:https://www.mdpi.com/2813-0464/4/2/25
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