Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.

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The ovary is one of the first organs to exhibit signs of aging, characterized by reduced tissue function, chronic inflammation, and fibrosis. Multinucleated giant cells (MNGCs), formed by macrophage fusion, typically occur in chronic immune pathologies, including infectious and non-infectious granul...

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Bibliographic Details
Main Authors: Aubrey Converse, Madeline J Perry, Shweta S Dipali, Jose V V Isola, Emmett B Kelly, Joseph M Varberg, Mary B Zelinski, Michael B Stout, Michele T Pritchard, Francesca E Duncan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003204
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