Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.

Show other versions (1)

The ovary is one of the first organs to exhibit signs of aging, characterized by reduced tissue function, chronic inflammation, and fibrosis. Multinucleated giant cells (MNGCs), formed by macrophage fusion, typically occur in chronic immune pathologies, including infectious and non-infectious granul...

Full description

Saved in:
Bibliographic Details
Main Authors: Aubrey Converse, Madeline J Perry, Shweta S Dipali, Jose V V Isola, Emmett B Kelly, Joseph M Varberg, Mary B Zelinski, Michael B Stout, Michele T Pritchard, Francesca E Duncan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003204
Tags: Add Tag
No Tags, Be the first to tag this record!
Login for hold and recall information

Internet

https://doi.org/10.1371/journal.pbio.3003204

Similar Items