Translational minimal physiologically based pharmacokinetic model for transferrin receptor-mediated brain delivery of antibodies
Successful development of monoclonal antibodies (mAbs) for the treatment of central nervous system disorders has been challenging due to their minimal ability to cross the blood–brain barrier (BBB), resulting in poor brain exposure. Bispecific antibodies (bsAb) that bind to transmembrane protein exp...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | mAbs |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19420862.2025.2515414 |
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