Translational minimal physiologically based pharmacokinetic model for transferrin receptor-mediated brain delivery of antibodies

Translational minimal physiologically based pharmacokinetic model for transferrin receptor-mediated brain delivery of antibodies

Successful development of monoclonal antibodies (mAbs) for the treatment of central nervous system disorders has been challenging due to their minimal ability to cross the blood–brain barrier (BBB), resulting in poor brain exposure. Bispecific antibodies (bsAb) that bind to transmembrane protein exp...

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Bibliographic Details
Main Authors: Morris Muliaditan, Tamara J. van Steeg, Lindsay B. Avery, Wei Sun, Timothy R. Hammond, Diana Hijdra, Siak-Leng Choi, Nikhil Pillai, Nina C. Leksa, Panteleimon D. Mavroudis
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
TfR shuttling
mPBPK modeling
model-informed drug development (MIDD)
brain delivery
pharmacokinetics (PK)
Bispecific antibodies
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2515414
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2515414

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