A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma

A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma

IntroductionHepatocellular carcinoma (HCC) ranks among the three most prevalent cancer-related diseases in terms of incidence. Hence, exploring drugs for HCC therapy is of great significance. Compounds with a diaryl urea structure have been reported to exhibit a broad range of biological activities,...

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Bibliographic Details
Main Authors: Yue Fu, Weiyue Fang, Fuqiang Qiu, Juncai Lai, Yangjin Xu, Bin Chen, Yang Li, Xiaohui Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
hepatocellular carcinoma
diaryl urea derivative
cell proliferation
RAS/RAF/MEK/ERK
bioactive compound
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1605515/full
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