Effectiveness and cost-effectiveness of community-based TB screening algorithms using computer-aided detection (CAD) technology alone compared with CAD combined with point-of-care C reactive protein testing in Lesotho and South Africa: protocol for a paired screen-positive trial

Effectiveness and cost-effectiveness of community-based TB screening algorithms using computer-aided detection (CAD) technology alone compared with CAD combined with point-of-care C reactive protein testing in Lesotho and South Africa: protocol for a paired screen-positive trial

Introduction Tuberculosis (TB) remains a significant public health challenge in many African communities, where underreporting and underdiagnosis are prevalent due to barriers in accessing care and inadequate diagnostic tools. This is particularly concerning in hard-to-reach areas with a high burden...

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Main Authors: Fabrizio Tediosi, Klaus Reither, Bram van Ginneken, Alastair van Heerden, Tinne Gils, Lutgarde Lynen, Josephine Muhairwe, Alfred Kipyegon Keter, Aita Signorell, Rediet Fikru Gebresenbet, Irene Ayakaka, Thomas Zoller, Fiona Vanobberghen, Mashaete Kamele, Thandanani Madonsela, Shannon Bosman, Anna Verjans, Bart Karl Jacobs, Curdin Brugger, Marina Antillon, Niklaus Daniel Labhardt, Harsh Vivek Harkare, Mamatlakeng Keitseng, Johanna Kurscheid, Keelin Murphy, Bulemba Katende, Rahel Milena Erhardt, Tracy R Glass
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/7/e093989.full
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