FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS
Abstract. Clinical and immunological examination was performed in a group of 120 patients with community-acquired pneumonia. The study included determination of humoral and cellular immunity factors, T-lymphocytes, T cell subpopulations and B cells in peripheral blood, measurements of circulating im...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/247 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839571682664120320 |
|---|---|
| author | G. A. Mavziutova R. M. Fazlyeva E. B. Tiurina R. M. Khairullina N. R. Bikmetova |
| author_facet | G. A. Mavziutova R. M. Fazlyeva E. B. Tiurina R. M. Khairullina N. R. Bikmetova |
| author_sort | G. A. Mavziutova |
| collection | DOAJ |
| description | Abstract. Clinical and immunological examination was performed in a group of 120 patients with community-acquired pneumonia. The study included determination of humoral and cellular immunity factors, T-lymphocytes, T cell subpopulations and B cells in peripheral blood, measurements of circulating immune complexes, phagocytic activities of peripheral neutrophils, studies of cytokines (IL-2, IL-4, IL-6, IL-8, TNFalpha) in the course of disease. Abnormalities of immune response were found that determined the severity of pneumonia and extent of inflammatory lung affection. Insufficiency of phagocytic protection and abnormality of immune complex elimination, reduced activity of effector T cells, with underlying increased reaction of NK cells, deficiency of humoral immunity factors, as reduced B-lymphocyte levels, as well as a trend to decrease in in IgM and IgG levels, may, in sum, determine a severe clinical course, along with lobular affection of lungs in community-acquired pneumonia. Imbalance of cytokines, with predominant proinflammatory activity and reduced regulatory functions may represent a significant reason of these immune disturbances, thus justifying a need for development of immunomodulatory therapy. |
| format | Article |
| id | doaj-art-b6adfbb9e51a4b5ea9cbf8a6514d337a |
| institution | Matheson Library |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-b6adfbb9e51a4b5ea9cbf8a6514d337a2025-08-04T14:30:29ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-019660561210.15789/1563-0625-2007-6-605-612244FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIASG. A. Mavziutova0R. M. Fazlyeva1E. B. Tiurina2R. M. Khairullina3N. R. Bikmetova4Башкирский государственный медицинский университет, г. УфаБашкирский государственный медицинский университет, г. УфаБашкирский государственный медицинский университет, г. УфаБашкирский государственный медицинский университет, г. УфаБашкирский государственный медицинский университет, г. УфаAbstract. Clinical and immunological examination was performed in a group of 120 patients with community-acquired pneumonia. The study included determination of humoral and cellular immunity factors, T-lymphocytes, T cell subpopulations and B cells in peripheral blood, measurements of circulating immune complexes, phagocytic activities of peripheral neutrophils, studies of cytokines (IL-2, IL-4, IL-6, IL-8, TNFalpha) in the course of disease. Abnormalities of immune response were found that determined the severity of pneumonia and extent of inflammatory lung affection. Insufficiency of phagocytic protection and abnormality of immune complex elimination, reduced activity of effector T cells, with underlying increased reaction of NK cells, deficiency of humoral immunity factors, as reduced B-lymphocyte levels, as well as a trend to decrease in in IgM and IgG levels, may, in sum, determine a severe clinical course, along with lobular affection of lungs in community-acquired pneumonia. Imbalance of cytokines, with predominant proinflammatory activity and reduced regulatory functions may represent a significant reason of these immune disturbances, thus justifying a need for development of immunomodulatory therapy.https://www.mimmun.ru/mimmun/article/view/247community-acquired pneumoniaimmunitycytokinesil-2il-4il-6il-8tnfalpha |
| spellingShingle | G. A. Mavziutova R. M. Fazlyeva E. B. Tiurina R. M. Khairullina N. R. Bikmetova FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS Медицинская иммунология community-acquired pneumonia immunity cytokines il-2 il-4 il-6 il-8 tnfalpha |
| title | FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS |
| title_full | FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS |
| title_fullStr | FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS |
| title_full_unstemmed | FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS |
| title_short | FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS |
| title_sort | features of immune disturbances in community acquired pneumonias |
| topic | community-acquired pneumonia immunity cytokines il-2 il-4 il-6 il-8 tnfalpha |
| url | https://www.mimmun.ru/mimmun/article/view/247 |
| work_keys_str_mv | AT gamavziutova featuresofimmunedisturbancesincommunityacquiredpneumonias AT rmfazlyeva featuresofimmunedisturbancesincommunityacquiredpneumonias AT ebtiurina featuresofimmunedisturbancesincommunityacquiredpneumonias AT rmkhairullina featuresofimmunedisturbancesincommunityacquiredpneumonias AT nrbikmetova featuresofimmunedisturbancesincommunityacquiredpneumonias |