Intrinsic Disorder and Phase Separation Coordinate Exocytosis, Motility, and Chromatin Remodeling in the Human Acrosomal Proteome

Intrinsic disorder refers to protein regions that lack a fixed three−dimensional structure under physiological conditions, enabling conformational plasticity. This flexibility allows for diverse functions, including transient interactions, signaling, and phase separation via disorder-to-order transi...

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Bibliographic Details
Main Authors: Shivam Shukla, Sean S. Lastorka, Vladimir N. Uversky
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Proteomes
Subjects:
Online Access:https://www.mdpi.com/2227-7382/13/2/16
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