Comparative cohort study of post-acute COVID-19 infection with a nested, randomized controlled trial of ivabradine for those with postural orthostatic tachycardia syndrome (the COVIVA study)

BackgroundSignificant clinical similarities have been observed between the recently described “Long-Haul” COVID-19 (LHC) syndrome, Postural Orthostatic Tachycardia Syndrome (POTS) and Inappropriate Sinus Tachycardia (IST). Shared symptoms include light-headedness, palpitations, tremulousness, genera...

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Main Authors:	David Saunders, Thomas B. Arnold, Jason M. Lavender, Daoqin Bi, Karl Alcover, Lydia D. Hellwig, Sahar T. Leazer, Roshila Mohammed, Bethelhem Markos, Kanchana Perera, Dutchabong Shaw, Priscilla Kobi, Martin Evans, Autumn Mains, Marian Tanofsky-Kraff, Emilie Goguet, Edward Mitre, Kathleen P. Pratt, Clifton L. Dalgard, Mark C. Haigney
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Neurology
Subjects:	severe acute respiratory syndrome coronavirus 2 long-haul COVID-19 postural orthostatic tachycardia syndrome ivabradine (Procoralan) clinical trial
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2025.1550636/full
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https://www.frontiersin.org/articles/10.3389/fneur.2025.1550636/full

Comparative cohort study of post-acute COVID-19 infection with a nested, randomized controlled trial of ivabradine for those with postural orthostatic tachycardia syndrome (the COVIVA study)

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