Interpreting immune evasion: a novel assay for HLA loss detection

Interpreting immune evasion: a novel assay for HLA loss detection

This study presents the analytical performance of a new Next-Generation Sequencing (NGS) assay designed to detect Human Leukocyte Antigen (HLA) loss. Unlike existing methods, this assay offers increased sensitivity, broader applicability, and does not require prior knowledge of specific HLA mismatch...

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Bibliographic Details
Main Authors: Linnéa Pettersson, Sofia Westerling, Hamid Ramezanali, Francesco Vezzi, Rikard Eckerud, Dan Hauzenberger, Anders Hedrum, Jonas Mattsson, Michael Uhlin, Mehmet Uzunel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
HSCT
NGS
HLA loss
immune evasion
haplo identical hematopoietic stem cell transplantation
MMUD-HSCT
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603188/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603188/full

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