Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

The common, late onset form of Alzheimer’s disease (AD) selectively impacts higher brain circuits, with tau pathology and neurodegeneration preferentially afflicting glutamatergic neurons in the limbic and association cortices. Understanding this selective vulnerability may help reveal the etiology...

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Bibliographic Details
Main Authors: Amy F. T. Arnsten, Isabella Perone, Min Wang, Shengtao Yang, Stacy Uchendu, Dinara Bolat, Dibyadeep Datta
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1610350/full
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