Endosomal disruption by co-encapsulating gentamicin in lipid nanoparticles for efficient siRNA delivery and cancer therapy

Endosomal disruption by co-encapsulating gentamicin in lipid nanoparticles for efficient siRNA delivery and cancer therapy

Efficient siRNA delivery is highly desirable for disease treatment. However, the application of conventional nanoparticles is limited by the inability to escape from endo-lysosomes. Herein, we report a strategy using small-molecule drugs to enhance siRNA endo‐lysosomal release,addressing this challe...

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Bibliographic Details
Main Authors: Ning Yang, Qi Sun, Yaoqi Wang, Dong Mei, Xiaoling Wang, Jie Zhang, Danni Liu, Ran Huo, Yang Tian, Yan Su, Shuang Zhang, Chunying Cui
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Sirna delivery
Gentamicin
Endosomal disruption
Cancer therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087624001284
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http://www.sciencedirect.com/science/article/pii/S1818087624001284

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