The host genes influencing Clostridioides difficile infection and the potential role of intestinal Lactobacillus acidophilus: a Mendelian randomization and animal model study

The host genes influencing Clostridioides difficile infection and the potential role of intestinal Lactobacillus acidophilus: a Mendelian randomization and animal model study

IntroductionClostridioides difficile infection (CDI) poses a significant clinical burden due to its high recurrence rate and life-threatening complications. While gut dysbiosis is central to CDI pathogenesis, mechanisms underlying microbiota-mediated host defense remain underexplored.MethodsThis stu...

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Main Authors: Yuxin Sun, Wenzhen Zhou, Senlin Ma, Qiuxin Lu, Yinuo Yuan, Yanchao Zheng, Yifan Yang, Kangshuai Zhou, Qingjiang Chen, Gonghao Sun, Zhaoming Shang, Junwei Qian, Xiaofei Jiang, Mingquan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Clostridioides difficile infection
gut probiotics
lactobacillus acidophilus
THOC5 gene
Mendelian randomization
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1607476/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1607476/full

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