The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal Infection
Relevance. Infections caused by methicillin-resistant strains of Staphylococcus aureus are an urgent problem of hospital epidemiology, and control measures involve the development of new antimicrobials. Probiotics based on bacterial strains isolated fro natural habitats are considered promising mean...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2024-01-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/1906 |
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| author | B. I. Aslanov V. V. Kolodzhieva E. A. Lebedeva I. A. Tumanyan Yu. D. Won A. S. Mokhov A. A. Dolgiy A. E. Goncharov |
| author_facet | B. I. Aslanov V. V. Kolodzhieva E. A. Lebedeva I. A. Tumanyan Yu. D. Won A. S. Mokhov A. A. Dolgiy A. E. Goncharov |
| author_sort | B. I. Aslanov |
| collection | DOAJ |
| description | Relevance. Infections caused by methicillin-resistant strains of Staphylococcus aureus are an urgent problem of hospital epidemiology, and control measures involve the development of new antimicrobials. Probiotics based on bacterial strains isolated fro natural habitats are considered promising means of combating MRSA.Aims. To test the possibility of using the Bacillus safensis 440-1 strain isolated from Antarctic soil. as an antibacterial agent for the treatment of experimental staphylococcal infection.Purpose of the study – check the possibility of using the Bacillus safensis 440-1 strain, isolated from Antarctic soil, as a topical antibacterial agent for the treatment of experimental staphylococcal infection.Material and methods. The potential virulence of Bacillus safensis strain 440-1 was studied on a mouse peritonitis model, and its activity against the methicillin-resistant Staphylococcus aureus SA776 test strain was studied on a localized wound infection model.Results and discussion. Our study demonstrated the safety of the tested strain due intraperitoneal use. We found that the use of the studied strain reduces the staphylococci amount in wounds from the third day from the start of the study to the end of the observation period, without aggravating the course of the infection.Conclusion. Bacillus safensis strain is a promising potential probiotic and it can be used as a part of complex antiseptic or disinfectant after additional studies aimed at developing an optimal mode of its use. |
| format | Article |
| id | doaj-art-b09a097ba8d74a30a38f54d64d71b77a |
| institution | Matheson Library |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-b09a097ba8d74a30a38f54d64d71b77a2025-08-04T13:02:06ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942024-01-01226667110.31631/2073-3046-2023-22-6-66-71990The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal InfectionB. I. Aslanov0V. V. Kolodzhieva1E. A. Lebedeva2I. A. Tumanyan3Yu. D. Won4A. S. Mokhov5A. A. Dolgiy6A. E. Goncharov7North-Western State Medical University named after I.I. Mechnikov of the Russian Ministry of HealthNorth-Western State Medical University named after I.I. Mechnikov of the Russian Ministry of HealthNorth-Western State Medical University named after I.I. Mechnikov of the Russian Ministry of HealthFederal State Budgetary Institution «National Medical Research Center of Oncology named after. N.N. Petrova» of the Ministry of HealthFederal State Budgetary Institution «National Medical Research Center of Oncology named after. N.N. Petrova» of the Ministry of HealthNorth-Western State Medical University named after I.I. Mechnikov of the Russian Ministry of Health; Institute of Experimental MedicineNorth-Western State Medical University named after I.I. Mechnikov of the Russian Ministry of HealthNorth-Western State Medical University named after I.I. Mechnikov of the Russian Ministry of Health; Institute of Experimental MedicineRelevance. Infections caused by methicillin-resistant strains of Staphylococcus aureus are an urgent problem of hospital epidemiology, and control measures involve the development of new antimicrobials. Probiotics based on bacterial strains isolated fro natural habitats are considered promising means of combating MRSA.Aims. To test the possibility of using the Bacillus safensis 440-1 strain isolated from Antarctic soil. as an antibacterial agent for the treatment of experimental staphylococcal infection.Purpose of the study – check the possibility of using the Bacillus safensis 440-1 strain, isolated from Antarctic soil, as a topical antibacterial agent for the treatment of experimental staphylococcal infection.Material and methods. The potential virulence of Bacillus safensis strain 440-1 was studied on a mouse peritonitis model, and its activity against the methicillin-resistant Staphylococcus aureus SA776 test strain was studied on a localized wound infection model.Results and discussion. Our study demonstrated the safety of the tested strain due intraperitoneal use. We found that the use of the studied strain reduces the staphylococci amount in wounds from the third day from the start of the study to the end of the observation period, without aggravating the course of the infection.Conclusion. Bacillus safensis strain is a promising potential probiotic and it can be used as a part of complex antiseptic or disinfectant after additional studies aimed at developing an optimal mode of its use.https://www.epidemvac.ru/jour/article/view/1906bacillus safensisprobioticsexperimental wound infectionmrsaantibiotic resistancebioprospecting |
| spellingShingle | B. I. Aslanov V. V. Kolodzhieva E. A. Lebedeva I. A. Tumanyan Yu. D. Won A. S. Mokhov A. A. Dolgiy A. E. Goncharov The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal Infection Эпидемиология и вакцинопрофилактика bacillus safensis probiotics experimental wound infection mrsa antibiotic resistance bioprospecting |
| title | The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal Infection |
| title_full | The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal Infection |
| title_fullStr | The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal Infection |
| title_full_unstemmed | The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal Infection |
| title_short | The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal Infection |
| title_sort | effect of locally applied bacillus safensis strain 440 1 from antarctic soil on the course of experimental wound staphylococcal infection |
| topic | bacillus safensis probiotics experimental wound infection mrsa antibiotic resistance bioprospecting |
| url | https://www.epidemvac.ru/jour/article/view/1906 |
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