Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model

Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model

Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells, which is involved in retinal ganglion cell apoptosis in glaucoma. Modulation of Kir4.1 expression in Müller cells may therefore be a po...

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Bibliographic Details
Main Authors: Fang Li, Zhen Li, Shuying Li, Hong Zhou, Yunhui Guo, Yongchen Wang, Bo Lei, Yanying Miao, Zhongfeng Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-04-01
Series:Neural Regeneration Research
Subjects:
apoptosis
chronic ocular hypertension
glial cell activation
kir4.1 overexpression
kir4.1 tyr9asp mutation
microglia
müller cells
neuroinflammation
neuroprotection
retinal ganglion cells
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00461
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