Repurposing losartan potassium against rheumatoid arthritis via transdermally-delivered leciplexes: Accentuated efficacy through modulation of angiotensin II/AT1R/AT2R axis

Repurposing losartan potassium against rheumatoid arthritis via transdermally-delivered leciplexes: Accentuated efficacy through modulation of angiotensin II/AT1R/AT2R axis

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory ailment which preferentially impacts the synovial membranes of joints and ultimately triggers cartilage and bone erosion. Angiotensin II (Ang II) participates in the pathogenesis of RA; hence, Ang II receptor blockade, accomplished throu...

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Bibliographic Details
Main Authors: Amira A. Hussein, Basmah N. Aldosari, Randa M. Zaki, Obaid Afzal, Adel A. Ali, Heba M. Aboud, Yasmin M. Ahmed, Demiana M. Naguib
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Rheumatoid arthritis
Losartan potassium
Transdermal delivery
Leciplexes
Complete Freund's adjuvant
Angiotensin II/AT1R/AT2R
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156725000398
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