Ultrasound-induced mechanical damage of cancer cell cytoskeleton causes disruption of nuclear envelope and activation of cGAS-STING

Ultrasound-induced mechanical damage of cancer cell cytoskeleton causes disruption of nuclear envelope and activation of cGAS-STING

Abstract Neoplastic transformation is accompanied by critical changes in cell mechanical properties, including reduced cell elasticity. By leveraging such mechanical flaw, exposure to low intensity therapeutic ultrasounds (LITUS) has been proposed as a tool for selective killing of cancer cells. Her...

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Bibliographic Details
Main Authors: Giorgia Federico, Angelo Rosario Carotenuto, Arsenio Cutolo, Stefania Palumbo, Marialuisa Moccia, Simona Paladino, Massimo Santoro, Tommaso Russo, Massimiliano Fraldi, Francesca Carlomagno
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
LITUS
Prostate cancer
LINC
DNA damage
cGAS-STING
Cell mechanics
Online Access:https://doi.org/10.1038/s41598-025-03317-9
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https://doi.org/10.1038/s41598-025-03317-9

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