Generation of the ICGi019-B-1 and ICGi019-B-2 lines via correction of the p.Met659Ile (c.1977G>A) variant in MYH7 of patient-specific induced pluripotent stem cells using CRISPR/Cas9

Generation of the ICGi019-B-1 and ICGi019-B-2 lines via correction of the p.Met659Ile (c.1977G>A) variant in MYH7 of patient-specific induced pluripotent stem cells using CRISPR/Cas9

The problem of interpretation of the genetic data from patients with inherited cardiovascular diseases still remains relevant. To date, the clinical significance of approximately 40 % of variants in genes associated with in herited cardiovascular diseases is uncertain, which requires new approaches...

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Bibliographic Details
Main Authors: A. E. Shulgina, S. V. Pavlova, J. M. Minina, S. M. Zakian, E. V. Dementyeva
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2025-06-01
Series:Вавиловский журнал генетики и селекции
Subjects:
hypertrophic cardiomyopathy
variants of unknown significance
induced pluripotent stem cells
crispr/cas9
Online Access:https://vavilov.elpub.ru/jour/article/view/4601
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