High cereblon expression in neuroendocrine cancer confers vulnerability to GSPT1 molecular glue degrader

High cereblon expression in neuroendocrine cancer confers vulnerability to GSPT1 molecular glue degrader

Abstract Background Recent advances in targeted therapies have introduced molecular glue degraders (MGDs) that leverage the cereblon (CRBN) E3 ubiquitin ligase to degrade the translation termination factor GSPT1. Understanding the cellular context for the selective targeting of cancer cells by GSPT1...

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Bibliographic Details
Main Authors: Jaewoo Park, Min Sung Joo, Myung Jun Kim, Seungseok Oh, Phuong Thao Tran, Minju Kwon, Yong June Choi, JaeYung Lee, Eun-Jung Kim, Dong Hyuk Ki, Hunmi Choi, Wooseok Han, Keon Wook Kang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Experimental Hematology & Oncology
Subjects:
Molecular glue degrader
Neuroendocrine cancer
CRBN
GSPT1
Biomarker
Online Access:https://doi.org/10.1186/s40164-025-00674-z
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