DNA Methylation of <i>Igf2r</i> Promoter CpG Island 2 Governs <i>Cis</i>-Acting Inheritance and Gene Dosage in Equine Hybrids

Genomic imprinting is critical for mammalian development, but its regulation varies across species. The insulin-like growth factor 2 receptor (IGF2R), which is a maternally expressed imprinted gene critical for cell proliferation and differentiation, as well as embryonic and placental development, i...

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Bibliographic Details
Main Authors: Xisheng Wang, Yingchao Shen, Hong Ren, Minna Yi, Gerelchimeg Bou
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biology
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Online Access:https://www.mdpi.com/2079-7737/14/6/678
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