Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot study
Introduction: Pathological scars, despite the achievements of modern medicine, are still a problem. Its prevalence can reach up to 50% in emergency surgeries. These scars can lead to physical complications, including impaired mobility, altered sensation, and discoloration, and may even cause pain....
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AboutScience Srl
2025-07-01
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| Online Access: | https://journals.aboutscience.eu/index.php/aboutopen/article/view/3521 |
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| author | Svitlana Korkunda Galina Gubina-Vakulik Jorge López-Berroa |
| author_facet | Svitlana Korkunda Galina Gubina-Vakulik Jorge López-Berroa |
| author_sort | Svitlana Korkunda |
| collection | DOAJ |
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Introduction: Pathological scars, despite the achievements of modern medicine, are still a problem. Its prevalence
can reach up to 50% in emergency surgeries. These scars can lead to physical complications, including
impaired mobility, altered sensation, and discoloration, and may even cause pain. In this study, we explore the
possibilities of using the combined drug of recombinant collagenase and lyase enzymes, and high molecular
weight hyaluronic acid (HMWHA) pbserum HIGH in the treatment of pathological scars.
Methods: patients of the main group received a course of intra-cicatricial injections of the drug, treatment results
were assessed clinically, according to the Vancouver Scar Scale (VSS) and Observer Scar Assessment Scale (POSAS)
scales, the results were compared morphologically with standard scars treatment methods (biopsies were taken
before and after treatment).
Results: Clinically, patients of the main group received a pronounced positive transformation of scar tissue in 6
weeks, statistical processing of data confirms the reliability of changes, morphological studies prove the normotrophic nature of the changes in the scars (including comparison with the control group).
Conclusions: Remedy of recombinant collagenase and lyase enzymes in combination with HMWHA pbserum HIGH
in the form of the course of intra-cicatricial injections is a safe and effective method of treating pathological scars.
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| format | Article |
| id | doaj-art-a828c5dfbe40465c99ee8633db3e65a5 |
| institution | Matheson Library |
| issn | 2465-2628 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | AboutScience Srl |
| record_format | Article |
| series | AboutOpen |
| spelling | doaj-art-a828c5dfbe40465c99ee8633db3e65a52025-07-25T14:22:40ZengAboutScience SrlAboutOpen2465-26282025-07-0112110.33393/ao.2025.3521Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot studySvitlana Korkunda 0Galina Gubina-Vakulik1Jorge López-Berroa2Department of Combustiology, Reconstructive and Plastic Surgery, Kharkiv Medical Academy of Post-graduate Education, Kharkiv - UkraineDepartment of Pathological Anatomy of the Kharkiv National Medical University, Kharkiv - UkraineGlobal Medical Department. Proteos Biotech. S.L., Madrid - Spain Introduction: Pathological scars, despite the achievements of modern medicine, are still a problem. Its prevalence can reach up to 50% in emergency surgeries. These scars can lead to physical complications, including impaired mobility, altered sensation, and discoloration, and may even cause pain. In this study, we explore the possibilities of using the combined drug of recombinant collagenase and lyase enzymes, and high molecular weight hyaluronic acid (HMWHA) pbserum HIGH in the treatment of pathological scars. Methods: patients of the main group received a course of intra-cicatricial injections of the drug, treatment results were assessed clinically, according to the Vancouver Scar Scale (VSS) and Observer Scar Assessment Scale (POSAS) scales, the results were compared morphologically with standard scars treatment methods (biopsies were taken before and after treatment). Results: Clinically, patients of the main group received a pronounced positive transformation of scar tissue in 6 weeks, statistical processing of data confirms the reliability of changes, morphological studies prove the normotrophic nature of the changes in the scars (including comparison with the control group). Conclusions: Remedy of recombinant collagenase and lyase enzymes in combination with HMWHA pbserum HIGH in the form of the course of intra-cicatricial injections is a safe and effective method of treating pathological scars. https://journals.aboutscience.eu/index.php/aboutopen/article/view/3521CollagenaseHyaluronic acidLyaseProgramed scar remodelingRecombinant enzymesScars |
| spellingShingle | Svitlana Korkunda Galina Gubina-Vakulik Jorge López-Berroa Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot study AboutOpen Collagenase Hyaluronic acid Lyase Programed scar remodeling Recombinant enzymes Scars |
| title | Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot study |
| title_full | Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot study |
| title_fullStr | Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot study |
| title_full_unstemmed | Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot study |
| title_short | Effectiveness study of the recombinant enzymes pbserum HIGH in the treatment of pathological scars: a pilot study |
| title_sort | effectiveness study of the recombinant enzymes pbserum high in the treatment of pathological scars a pilot study |
| topic | Collagenase Hyaluronic acid Lyase Programed scar remodeling Recombinant enzymes Scars |
| url | https://journals.aboutscience.eu/index.php/aboutopen/article/view/3521 |
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