Serum NPTX2 and cognitive impairment in geriatric diabetes: A cross-sectional study
Cognitive impairment is an increasingly common complication of diabetes, yet its underlying pathophysiological mechanisms remain poorly understood. Neuronal pentraxin 2 (NPTX2), a recently identified synaptic biomarker linked to cognitive disorders, has not previously been examined in relation to c...
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-07-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/12632 |
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| author | Kenan Çadırcı Muharrem Bayrak Alev Lazoğlu Özkaya Gamze Nur Yılmaz Nur Pak Büşra Karahan Hilal Kiziltunc Ozmen |
| author_facet | Kenan Çadırcı Muharrem Bayrak Alev Lazoğlu Özkaya Gamze Nur Yılmaz Nur Pak Büşra Karahan Hilal Kiziltunc Ozmen |
| author_sort | Kenan Çadırcı |
| collection | DOAJ |
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Cognitive impairment is an increasingly common complication of diabetes, yet its underlying pathophysiological mechanisms remain poorly understood. Neuronal pentraxin 2 (NPTX2), a recently identified synaptic biomarker linked to cognitive disorders, has not previously been examined in relation to cognitive function in geriatric individuals with diabetes. This cross-sectional study enrolled 90 participants—46 geriatric patients with diabetes and 44 age-matched non-diabetic controls. Demographic and clinical data were collected for all participants. After informed consent, cognitive function was assessed with the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Serum NPTX2 levels were measured by ELISA. No significant differences were found between the diabetic and control groups in age, sex, education level, marital status, smoking history, comorbid conditions, or polypharmacy. However, the groups differed significantly in MoCA scores (p < 0.001), MMSE scores (p = 0.028), and NPTX2 levels (p = 0.048); the diabetic group showed lower cognitive scores and biomarker levels. NPTX2 levels correlated positively with MoCA and MMSE scores and negatively with diabetes duration, patient age, and the presence of microvascular complications. In conclusion, cognitive function was significantly lower in geriatric patients with diabetes than in controls, and serum NPTX2 levels were significantly associated with cognitive performance. These findings suggest a possible role for NPTX2 in diabetes-related cognitive decline and support further investigation of its utility within a broader biomarker panel.
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| format | Article |
| id | doaj-art-a7df0bd9be804528900611a978ef33d6 |
| institution | Matheson Library |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj-art-a7df0bd9be804528900611a978ef33d62025-07-23T16:03:04ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-07-0110.17305/bb.2025.12632Serum NPTX2 and cognitive impairment in geriatric diabetes: A cross-sectional studyKenan Çadırcı0https://orcid.org/0009-0002-8902-0018Muharrem Bayrak1https://orcid.org/0000-0003-2760-4181Alev Lazoğlu Özkaya2https://orcid.org/0000-0002-2033-3692Gamze Nur Yılmaz3https://orcid.org/0000-0001-7682-0687Nur Pak4Büşra Karahan5https://orcid.org/0000-0001-5161-6751Hilal Kiziltunc Ozmen6Department of Internal Medicine, Erzurum Faculty of Medicine, Health Sciences University, Erzurum, TürkiyeDepartment of Internal Medicine, Erzurum Faculty of Medicine, Health Sciences University, Erzurum, TürkiyeDepartment of Biochemistry, Erzurum Faculty of Medicine, Health Sciences University, Erzurum, TürkiyeDepartment of Child Health and Diseases Nursing, Institute of Health Sciences, Atatürk University, Erzurum, TürkiyeDepartment of Internal Medicine Nursing, Institute of Health Sciences, Atatürk University, Erzurum, TürkiyeDepartment of Internal Medicine, Erzurum Faculty of Medicine, Health Sciences University, Erzurum, TürkiyeDepartment of Radiation Oncology, Faculty of Medicine, Atatürk University, Erzurum, Türkiye Cognitive impairment is an increasingly common complication of diabetes, yet its underlying pathophysiological mechanisms remain poorly understood. Neuronal pentraxin 2 (NPTX2), a recently identified synaptic biomarker linked to cognitive disorders, has not previously been examined in relation to cognitive function in geriatric individuals with diabetes. This cross-sectional study enrolled 90 participants—46 geriatric patients with diabetes and 44 age-matched non-diabetic controls. Demographic and clinical data were collected for all participants. After informed consent, cognitive function was assessed with the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Serum NPTX2 levels were measured by ELISA. No significant differences were found between the diabetic and control groups in age, sex, education level, marital status, smoking history, comorbid conditions, or polypharmacy. However, the groups differed significantly in MoCA scores (p < 0.001), MMSE scores (p = 0.028), and NPTX2 levels (p = 0.048); the diabetic group showed lower cognitive scores and biomarker levels. NPTX2 levels correlated positively with MoCA and MMSE scores and negatively with diabetes duration, patient age, and the presence of microvascular complications. In conclusion, cognitive function was significantly lower in geriatric patients with diabetes than in controls, and serum NPTX2 levels were significantly associated with cognitive performance. These findings suggest a possible role for NPTX2 in diabetes-related cognitive decline and support further investigation of its utility within a broader biomarker panel. https://www.bjbms.org/ojs/index.php/bjbms/article/view/12632Diabetes mellitusgeriatric patientscognitive dysfunctionneuronal pentraxin 2NPTX2 |
| spellingShingle | Kenan Çadırcı Muharrem Bayrak Alev Lazoğlu Özkaya Gamze Nur Yılmaz Nur Pak Büşra Karahan Hilal Kiziltunc Ozmen Serum NPTX2 and cognitive impairment in geriatric diabetes: A cross-sectional study Biomolecules & Biomedicine Diabetes mellitus geriatric patients cognitive dysfunction neuronal pentraxin 2 NPTX2 |
| title | Serum NPTX2 and cognitive impairment in geriatric diabetes: A cross-sectional study |
| title_full | Serum NPTX2 and cognitive impairment in geriatric diabetes: A cross-sectional study |
| title_fullStr | Serum NPTX2 and cognitive impairment in geriatric diabetes: A cross-sectional study |
| title_full_unstemmed | Serum NPTX2 and cognitive impairment in geriatric diabetes: A cross-sectional study |
| title_short | Serum NPTX2 and cognitive impairment in geriatric diabetes: A cross-sectional study |
| title_sort | serum nptx2 and cognitive impairment in geriatric diabetes a cross sectional study |
| topic | Diabetes mellitus geriatric patients cognitive dysfunction neuronal pentraxin 2 NPTX2 |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/12632 |
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