Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals

Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals

Objectives: Hypothalamic Fatty Acid Synthase (FASN) plays a critical role in regulating energy balance by influencing food intake and body weight. This study aimed to investigate the neuronal mechanisms by which FASN impacts metabolism, focusing on its role in Pro-Opiomelanocortin (POMC) neurons. Me...

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Bibliographic Details
Main Authors: Luis Leon-Mercado, Yanbin Dong, Bandy Chen, Arely Tinajero, Caleb C. Lord, Syann Lee, Chen Liu, Guosheng Liang, Jay D. Horton, Kevin W. Williams, Joel K. Elmquist
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular Metabolism
Subjects:
FASN (Fatty Acid Synthase)
POMC (Pro-Opiomelanocortin) neurons
Energy balance
Glucose metabolism
Adrenergic signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000845
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http://www.sciencedirect.com/science/article/pii/S2212877825000845

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