Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy

Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy

Pyroptosis is a critical process that triggers inflammatory responses and mitochondrial DNA (mtDNA) release, thereby activating the cGAS-STING pathway. However, tumor metabolism, particularly glycolysis, often suppresses immune activation. To address this, we developed GOCoF2, a self-amplifying pyro...

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Bibliographic Details
Main Authors: Linzhu Zhang, Di Wang, Yiming Liu, Nailin Yang, Shumin Sun, Chunjie Wang, Duo Wang, Jihu Nie, Juan Qin, Lei Zhang, Liang Cheng, Haidong Zhu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
Pyroptosis
cGAS-STING pathway
Glucose metabolism
CoF2 nanoenzymes
Transarterial embolization
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003330
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http://www.sciencedirect.com/science/article/pii/S2452199X25003330

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