Fucoxanthin mitigates aflatoxin B1-triggered hepatotoxicity in HepG2 cells via modulation of oxidative stress, inflammatory cytokines, and caspases cascade

Fucoxanthin mitigates aflatoxin B1-triggered hepatotoxicity in HepG2 cells via modulation of oxidative stress, inflammatory cytokines, and caspases cascade

Aflatoxins (AFB1) are harmful secondary metabolites generated by filamentous fungi with a profound hepatotoxic effect. Fucoxanthin (FX) is a flavonoid with a well-known cytoprotective action. Here, we evaluated the ability of FX to mitigate AFB1-triggered hepatotoxicity using the HepG2 cell line. Da...

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Main Authors: Ekramy M. Elmorsy, Afaf Abdelkader, Nagah E. Ali, Farouk S. Elgendy, Heba Allah M. Elbaghdady, Lina A. Mohammed, Hala M. Anwer, Amal S. Abu-Almakarem, Mohamed E. Mohamed, Ioana A. Hinda, Stefan Batrina, Lucian Botos, Ilinca Imbrea, Samah F. Ibrahim, Enas Shaban, Ahmed Abdeen
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Hepatocellular carcinoma
Molecular docking
Cytotoxicity
NRF2 pathway
CYP450 enzymes
Hepatotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325011224
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