A Brand-New Metal Complex Catalyst-Free Approach to the Synthesis of 2,8-Dimethylimidazo[1,2-<i>b</i>]pyridazine-6-Carboxylic Acid—A Key Intermediate in Risdiplam Manufacturing Process

A Brand-New Metal Complex Catalyst-Free Approach to the Synthesis of 2,8-Dimethylimidazo[1,2-<i>b</i>]pyridazine-6-Carboxylic Acid—A Key Intermediate in Risdiplam Manufacturing Process

In this study, we report for the first time a brand-new protocol for the multigram-scale synthesis of 5-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylic and 2,8-dimethylimidazo[1,2-<i>b</i>]pyridazine-6-carboxylic acids, without the utilization of metal-complex catalysts. The developed te...

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Bibliographic Details
Main Authors: Georgiy Korenev, Alexey A. Gutenev, Fyodor V. Antipin, Vladimir V. Chernyshov, Maria P. Korobkina, Maxim B. Nawrozkij, Roman A. Ivanov
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
spinal muscular atrophy (SMA)
risdiplam
small molecules
Online Access:https://www.mdpi.com/1420-3049/30/14/3011
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