Chromoanagenesis in Osteosarcoma

Chromoanagenesis in Osteosarcoma

Chromoanagenesis is a catastrophic genomic phenomenon involving sudden, extensive rearrangements within one or a few cell cycles. In osteosarcoma, the most prevalent malignant bone tumor in children and adolescents, these events dramatically alter the genomic landscape, frequently disrupting key tum...

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Bibliographic Details
Main Authors: Guozhuang Li, Nan Wu, Jen Ghabrial, Victoria Stinnett, Melanie Klausner, Laura Morsberger, Patty Long, Ezra Baraban, John M. Gross, Ying S. Zou
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
chromoanagenesis
osteosarcoma
structural variant
chromothripsis
chromoanasynthesis
copy number variant
Online Access:https://www.mdpi.com/2218-273X/15/6/833
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